EXAMPLE - an excerpt from the CAS Catalog
PSTA
The Packing Science and Technology Abstracts
database contains citations to the worldwide
literature on packaging science and technology,
with special emphasis on the packaging of
foodstuffs and pharmaceuticals. Coverage
includes packaging economy, packaging material,
processing and production machines, packages,
packaging accessories, goods to be packed,
packaging machines, packs, research, standards,
quality control, testing and stress loading,
wrapping, transport and storage, and waste
recycling. Sources include more than 350
periodicals, as well as books, pamphlets, patents,
standards, specifications, legislation,
conference papers, research reports, and trade
literature.
Producer: Fraunhofer-Institut fuer
Lebensmitteltechnologie
und Verpackung
Coverage: 1981 to date
File Size: 39,500
Updates: Bimonthly
File Type: Bibliographic
Content: Packaging science and
technology
Language: English and German
Cluster: ALLBIB, AUTHORS,
BUSINESS, CORP-
SOURCE, ENGINEERING,
ENVIRONMENT,
MATERIALS
EXAMPLE - of Basic Indexes
An STN record from the BIOSIS database:
(Words in red make up the Basic Index)
AN 95:490004 BIOSIS
DN 98504304
TI Synthesis and Serotonergic Activity of Arylpiperazide Derivatives
of Serotonin:Potent Agonists for 5-HT-1D Receptors.
AU Perez M; Fourrier C; Sigogneau I; Pauwels P J; Palmier C; John G W;
Valentin J-P; Halazy S
CS Med. Chem. Div., Cell. Mol. Neurobiol., Lab. Cardiovasc. Dis. Div.,
Cent. Rech. Pierre Fabre, 17 Ave. Jean Moulin, 81106 Castres Cedex,
France
SO Journal of Medicinal Chemistry 38 (18). 1995. 3602-3607. ISSN:
0022-2623
LA English
PR Biological Abstracts Vol. 100 Iss. 010 Ref. 155161
AB A series of new arylpiperazide derivatives of serotonin has been
prepared and evaluated as 5-HT-1D receptor agonists. Binding
experiments at cloned human 5-HT-1Dalpha, 5-HT-1Dbeta, and 5-HT-1A
receptors show that all the compounds are very potent and selective
ligands for 5-HT-1D receptor subtypes. Functional activity studies
(contraction of the New Zealand white rabbit saphenous vein)
demonstrate that most of the derivatives behave as full agonists.
Among them, the aryl sulfonamide derivative 5q (pD-2= 8.33 compare to
5.75 for sumatriptan) was also identified as a very potent agonist in
inhibiting the forskolin-mediated cyclase coupled to 5-HT-1Dbeta
receptors (EC-50 = 0.52 nM).
ST RESEARCH ARTICLE; HUMAN; RABBIT; MAMMAL; SUMATRIPTAN;
5-HYDROXYTRYPTAMINE; MIGRAINE HEADACHE; QUANTITATIVE
STRUCTURE-ACTIVITY RELATIONSHIP; SYNTHETIC METHOD; PHARMACEUTICALS
RN 50-67-9 (5-HYDROXYTRYPTAMINE)
50-67-9D (SEROTONIN)
103628-46-2 (SUMATRIPTAN)
CC Biochemical Studies-General *10060
Biochemical Studies-Proteins, Peptides and Amino Acids *10064
Biophysics-Molecular Properties and Macromolecules *10506
Biophysics-Membrane Phenomena *10508
Chordate Body Regions-Head 11304
Cardiovascular System-Blood Vessel Pathology 14508
Endocrine System-Neuroendocrinology *17020
Nervous System-Physiology and Biochemistry *20504
Nervous System-Pathology 20506
Pharmacology-General *22002
Pharmacology-Cardiovascular System *22010
Pharmacology-Neuropharmacology *22024
BC Leporidae 86040
Hominidae 86215
Note that there is some variation in the field and index codes used by different databases (e.g., indexing terms may appear in the IT or ST data fields, among others). Codes are determined by consulting the Database Summary Sheets for the database of interest.
An STN record from the CAplus database:
(Words in red make up the Basic Index)
AN 1995:746798 CAPLUS
DN 123:285902
TI Synthesis and serotonergic activity of arylpiperazide derivatives
of serotonin: potent agonists for 5-HT1D receptors
AU Perez, Michel; Fourrier, Catherine; Sigogneau, Isabelle; Pauwels,
Petrus J.; Palmier, Christiane; John, Gareth W.; Valentin,
Jean-Pierre; Halazy, Serge
CS Medicinal Chemistry Division, Centre de Recherche Pierre Fabre,
Castres, 81106, Fr.
SO J. Med. Chem. (1995), 38(18), 3602-7
CODEN: JMCMAR; ISSN: 0022-2623
DT Journal
LA English
CC 28-17 (Heterocyclic Compounds (More Than One Hetero Atom))
Section cross-reference(s): 1
OS CASREACT 123:285902; CJACS-IMAGE; CJACS
GI
AB A series of new arylpiperazide derivs. of serotonin I (R1 = H, o-Me,
o- and p-O2N, p-H2N, p-PhCONH, p-MeSO2NH, p-Me2NSO2NH, etc.; n = 1,
3-5) has been prepd. and evaluated as 5-HT1D receptor agonists.
Binding expts. at cloned human 5-HT1D.alpha., 5-HT1D.beta., and
5-HT1A receptors showed that all the compds. are very potent and
selective ligands for 5-HT1D receptor subtypes. Functional activity
studies (contraction of the New Zealand white rabbit saphenous vein)
demonstrate that most of the derivs. behave as full agonists. Among
them, I (R1 = p-MeSO2NH, n = 5) (pD2 = 8.33 compared to 5.75 for
sumatriptan) was also identified as a very potent agonist in
inhibiting the forskolin-mediated cyclase coupled to 5-HT1D.beta.
receptors (EC50 = 0.52 nM). Structure-affinity relationships are
discussed.
ST serotonin arylpiperazide prepn serotoninergic agonist; piperazide
serotonin prepn serotoninergic agonist
IT Neurotransmitter agonists
(serotoninergic, 5-HT1D; synthesis and serotonergic
activity of arylpiperazide derivs. of serotonin)
IT 157694-56-9P 169777-68-8P 169777-69-9P 169777-70-2P
169777-71-3P 169777-72-4P 169777-73-5P 169777-74-6P
169777-75-7P 169777-76-8P 169777-77-9P 169777-78-0P
169777-79-1P 169777-80-4P 169777-81-5P 169777-82-6P
169777-83-7P 169777-84-8P 169777-85-9P 169777-86-0P
RL: BAC (Biological activity or effector, except adverse); SPN
(Synthetic preparation); THU (Therapeutic use); BIOL (Biological
study); PREP (Preparation); USES (Uses)
(synthesis and serotonergic activity of arylpiperazide
derivs. of serotonin)
IT 971-74-4, Serotonin creatinine sulfate 6269-89-2, Piperazine,
1-(4-Nitrophenyl)- 24424-99-5, Di-tert-butyl dicarbonate
169777-61-1 169777-62-2
RL: RCT (Reactant)
(synthesis and serotonergic activity of arylpiperazide
derivs. of serotonin)
IT 16264-11-2P 53157-48-5P 169777-63-3P 169777-64-4P
169777-65-5P 169777-66-6P 169777-67-7P
RL: RCT (Reactant); SPN (Synthetic preparation); PREP (Preparation)
(synthesis and serotonergic activity of arylpiperazide
derivs. of serotonin)
EXAMPLE - use of the AND operator (to search for terms in /BI of the PSTA file) AND
Combining two or more terms with AND retrieves those answers (records) containing each of the search terms.
For example:
=> S TAMPER AND PACKAGE
STN responds with: 430 TAMPER
9454 PACKAGE
118 TAMPER AND PACKAGE
The response from STN tells you that:
- 430 records contain the term TAMPER in the /BI of PSTA
- 9454 records contain the term PACKAGE in the /BI of PSTA
- 118 records contain both the term TAMPER and PACKAGE in the /BI of PSTA
EXAMPLE - use of the OR operator (to search for terms in /BI of the PSTA file) OR
Combining a set of terms with OR retrieves all answers that contain at least one of the search terms.
For example:
=> S TAMPER OR PACKAGE
STN responds with: 430 TAMPER
9454 PACKAGE
9766 TAMPER OR PACKAGE
The response from STN tells you that:
- 430 records contain the term TAMPER in the /BI of PSTA
- 9454 records contain the term PACKAGE in the /BI of PSTA
- 9766 records contain either TAMPER or PACKAGE or both in the /BI of PSTA
EXAMPLE - use of parentheses with operators (to search for terms in /BI of the PSTA file)
Search terms and logic operators in a search question are processed in a specific order by STN. For this reason, it is necessary to enclose terms connected by the OR operator in parentheses.
For example:
=> S TAMPER AND (PACKAGE OR CONTAINER)
STN responds with: 430 TAMPER
9454 PACKAGE
4886 CONTAINER
199 TAMPER AND (PACKAGE OR CONTAINER)
STN does the operation in parentheses first, then combines it with the TAMPER term using AND logic.
In contrast, without parentheses:
=> S TAMPER AND PACKAGE OR CONTAINER
STN responds with: 430 TAMPER
9454 PACKAGE
4886 CONTAINER
4985 TAMPER AND PACKAGE OR CONTAINER
* When parentheses are not used, STN processes the operators from left to right.
EXAMPLE - use of the NOT operator (to search for terms in /BI of the PSTA file) NOT
NOT eliminates all answers containing the search term following the NOT operator.
For example:
=> S TAMPER NOT PACKAGE
STN responds with: 430 TAMPER
9454 PACKAGE
312 TAMPER NOT PACKAGE
The response from STN tells you that:
- 312 records contain the term TAMPER but not the term PACKAGE in the /BI of PSTA
Updated 3/9/2007 1:06:51 PM
