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Ask REGgie: Locating biochemical data in CAS REGISTRYSM
Q: How can I find biochemistry-related information on sequences in REGISTRY? A: REGISTRY includes experimental property tags to help you locate biochemical data, including information on genetic polymorphisms and drug targets in the literature. The overlap of chemistry and the life sciences continues to grow in both size and significance. The content of CAS REGISTRY reflects this dynamic, and the database includes a significant amount of valuable biochemical and genetic data. As the sequencing of many prokaryotic and eukaryotic genomes is completed, and the encoded proteins are identified and characterized, DNA, RNA, and protein sequences are assigned CAS Registry Numbers. REGISTRY records and experimental property dataREGISTRY records include experimental property data and links to other STN databases that contain references to the sequence. The EPROP display format in REGISTRY allows you to display all of the available experimental property data. Example of a REGISTRY record for a sequence. L1 ANSWER 1 OF 12 REGISTRY COPYRIGHT 2008 ACS on STN
1 REFERENCES IN FILE CAPLUS (1907 TO DATE) Example of experimental property data available in REGISTRY. L1 ANSWER 10 OF 12 REGISTRY COPYRIGHT 2008 ACS on STN
Experimental property tagsTo elucidate a protein's biological function(s), it may be important to know its localization within the cell, interactions with other proteins, linkage to phenotypic traits, and/or post-translational modification(s). To organize this data and help compile it in a single location, new experimental property tags in REGISTRY refer to the genetic, biochemical, and molecular data associated with a given sequence or substance. These include:
To display biological and chemical property tags, you can use the ETAG field code. If a tag appears in the Experimental Property Tags (ETAG) table, information pertaining to that property is available for the given substance. To simplify finding records related to a property tag, reference information is given directly below the Experimental Property Tag table. When you click the link in the reference, the record of interest is displayed. For example, clicking the CAPLUS link at the end of reference 1 automatically accesses the CAplusSM database and displays the record containing allele frequency and heterozygosity data.
Example of experimental property tags in REGISTRY and links to CAplus. L1 ANSWER 4 OF 12 REGISTRY COPYRIGHT 2008 ACS on STN
United States) 2007 V53(7) P1199-1205 CAPLUS (2) Cosme, Jose Marie; WO 2003102192 A1 2003 CAPLUS (3) Zandvliet, Anthe S.; Clinical Cancer Research 2007 V13(10) P2970-2976 CAPLUS (4) Williams, Pamela Ann; US 2004053383 A1 2004 CAPLUS (5) Dickmann, Leslie J.; Molecular Pharmacology 2004 V65(4) P842-850 CAPLUS (6) Hummel, Matthew A.; Journal of Biomolecular Screening 2006 V11(3) P303-309 CAPLUS
=> FIL CAPLUS COPYRIGHT (C) 2008 AMERICAN CHEMICAL SOCIETY (ACS) => D ACC 2007:734929 IBIB IABS ANSWER 1 CAPLUS COPYRIGHT 2008 ACS on STN ACCESSION NUMBER: 2007:734929 CAPLUS DOCUMENT NUMBER: 147:86131 TITLE: Estimation of warfarin maintenance dose based on VKORCI (-1639 G>A) and CYP2C9 genotypes AUTHOR(S): Zhu, Yusheng; Shennan, Michael; Reynolds, Kristen K.; Johnson, Nancy A.; Herrnberger, Matthew R.; Valdes, Roland, Jr.; Linder, Mark W. . . . ABSTRACT: CYP2C9 polymorphisms are assocd. with decreased S-warfarin clearance and lower maintenance dosage. Decreased expression of VKORC1 resulting from the -1639G>A substitution has also been implicated in lower warfarin dose requirements. We investigated the addnl. contribution of this polymorphism . . . REFERENCE COUNT: 30 THERE ARE 30 CITED REFERENCES AVAILABLE FOR THIS RECORD. ALL CITATIONS AVAILABLE IN THE RE FORMAT Displaying all available property tagsInformation related to a property is often found in more than one reference. By default, the ETAG display format lists only one reference per property tag. However, you can display the full list of references by using the MAX or ETAGFULL display format. Example of MAX or ETAGFULL display. L1 ANSWER 4 OF 12 REGISTRY COPYRIGHT 2008 ACS on STN
Allele Frequency and Heterozygosity |(2) CAS Allele Frequency and Heterozygosity |(3) CAS Crystal Structure |(4) CAS Crystal Structure |(5) CAS Crystal Structure |(6) CAS Disease-Related Mutations |(3) CAS Genetic Polymorphism |(3) CAS Genetic Polymorphism |(1) CAS Genetic Polymorphism |(7) CAS Genetic Polymorphism |(2) CAS Human Disease-Related Mutations |(3) CAS Molecular Structure |(6) CAS UV and Visible Absorption Spectra |(8) CAS UV and Visible Emission/Luminescence Spectra |(9) CAS (1) Zhu, Yusheng; Clinical Chemistry (Washington, DC, United States) 2007 V53(7) P1199-1205 CAPLUS (2) Millican, Eric A.; Blood 2007 V110(5) P1511-1515 CAPLUS (3) Zandvliet, Anthe S.; Clinical Cancer Research 2007 V13(10) P2970-2976 CAPLUS (4) Cosme, Jose Marie; WO 2003102192 A1 2003 CAPLUS (5) Williams, Pamela Ann; WO 2003035693 A2 2003 CAPLUS (6) Williams, Pamela Ann; US 2004053383 A1 2004 CAPLUS (7) Beumer, Jan H.; Cancer Chemotherapy and Pharmacology 2007 V59(6) P825-837 CAPLUS (8) Dickmann, Leslie J.; Molecular Pharmacology 2004 V65(4) P842-850 CAPLUS (9) Hummel, Matthew A.; Journal of Biomolecular Screening 2006 V11(3) P303-309 CAPLUS
Multidisciplinary coverage within REGISTRYThe rate at which prokaryotic and eukaryotic genomes are being sequenced, and the encoded proteins are being identified and characterized, continues to increase. As vast amounts of new inormation are generated, databases play an increasingly vital role as central resources for organizing and storing this data. With the recent introduction of genetic and biological property tags, REGISTRY reflects the dynamic developments in chemistry, biology, and other sciences. Evolving in response to the overlap of scientific disciplines positions REGISTRY as a valuable resource not only for chemists but for all members of the scientific community.
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